High-amount SSB intake (>750 ml/day) was related to high weight and waist and hip circumferences (P<0.05), and increased SSB intake was linked to increased BMI values; serum UA, TG and RBP4 levels; overweight/obesity percentages and hyperuricemia (P for trend <0.05). This evidence concerns the gene RBP4 and obesity due to melanocortin 4 receptor deficiency.