[20], [21]. Alternatively, similar to findings from patients with type 2 diabetes [43], [44], a significant linear relationship exists between serum RBP4 and UA levels among healthy adolescents who consumed HFCS-rich HSD beverages (r = 0.253) and mixed sugar BSD beverages (r = 0.307). RBP4 is a novel cardiometabolic risk factor [9], and fructose-derived hyperuricemia may be a critical intermediate agent for the abnormalities of cardiometabolic risk factor [21], [38]. The gene discussed is RBP4; the disease is hyperuricemia.