Table 2 shows most post-IVMP LN patients improving SLEDAI score. CD8+ Treg cells from these patients showed strong suppressive function both in vitro and in vivo. Auto-antibodies against C1q are directed against a highly functional molecule with vital roles in autoimmunity. We proved strong correlation between occurrence of anti-C1q antibodies in Class III/IV LN. Increasing evidence shows inactive classic complement pathway definitely improved in Class III/IV LN, and CD8+ Treg cells seem to play a suppressing complement activation in classic pathway. The gene discussed is CD8A; the disease is Autoimmunity.