Comparing CD8+CD25+IL-10+ and granzyme B expressing CD8+CD25+ T cell numbers from PBMCs of LN patients before and after IVMP pulse therapy showed CD8+CD25+IL-10+ T cells significantly higher (7.88±3.16 vs 23.60±6.3970, P<0.05)(Fig. 3b), as did granzyme B expressing CD8+CD25+ T cells (10.28±3.10 vs 24.59±5.7570, P<0.05)(Fig. 3c). The gene discussed is CD8A; the disease is lobular neoplasia.