RIGI and melanoma: However, with a diverse range of innate immune receptors able to detect viral and bacterial pathogens, it may be possible to target the endosomal TLRs without compromising innate immunity due to compensation from the other cytosolic RNA and DNA receptors such as RIG-I (retinoic acid inducible gene-I) and AIM2 (absent in melanoma 2) (5).