The SDF-1-CXCR4 ligand receptor axis induces pancreatic cancer cell invasion, and the Src-mediated SDF-1 signaling is also an obligatory component of pancreatic regeneration (Takatomo et al., 2000; Kayali et al., 2003; Gao et al., 2010). Here, CXCL12 is linked to familial pancreatic carcinoma.