The gene functions in the development and maintenance of synaptic networks and may be under the regulatory control of DISC1. Many of the cases segregating the DISC1 translocation in the original Scottish schizophrenia pedigree were affected with schizoaffective disorder or mood disorders as was the case in the largest PAK7 pedigree we investigated, and we also found evidence for association with bipolar disorder (46). This evidence concerns the gene DISC1 and schizophrenia.