Previously, epigenetic silencing of Axin2 was reported in colorectal carcinoma with microsatellite instability (MSI+ CRC), and forced expression of Axin2 results in rapid cell death in an MSI+ CRC cell line, indicating a role of epigenetic silencing of Axin2 in carcinogenesis of MSI+ CRC (Koinuma et al., 2006). The gene discussed is AXIN2; the disease is colorectal carcinoma.