INS and early-onset autosomal dominant Alzheimer disease: Aberrant protein aggregation is a common feature of late-onset neurodegenerative diseases such as Alzheimer’s disease and inhibition of the insulin/IGF signaling pathway has been shown to reduce the toxic aggregate prone proteins in a worm model of Alzheimer’s disease (Cohen et al., 2006; Pinkston-Gosse and Kenyon, 2007).