A question remains to be answered is how reducing insulin signaling, which is associated with various aging-associated metabolic and cardiovascular diseases such as obesity, type 2 diabetes, and hypertension (Rowe et al., 1983; Kohrt et al., 1993; Finkel and Holbrook, 2000), extends lifespan. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.