Of the top 50 up-regulated hCM-specific genes we analyzed, 27 of them (54%) showed associations with at least one known cardiovascular diseases and 5 of them (NPPB, TNNT2, NPPA, RYR2, and PLN) were linked to more than 10 different types of cardiovascular diseases (Fig. 4A, Table S13). Here, RYR2 is linked to cardiovascular disorder.