In this regard, the known tumor promoters stimulated cancer progression by a CAR-dependent perturbation of the expression of the growth arrest and DNA damage-inducible 45 beta (GADD45B) (Columbano et al., 2005), the murine double minute 2 (mdm2) (Huang et al., 2005), as well as the newly identified tubulin alpha 8 (TUBA8) (Kamino et al., 2011a). Here, TUBA8 is linked to cancer.