In contrast to these observed roles of murine CAR in tumor development, activation of human (h) CAR by the selective activator, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehydeO-(3,4-dichlorobenzyl)oxime (CITCO), appears to be associated with cell cycle arrest and enhanced apoptosis in human brain tumor stem cells, illustrating an anti-cancer potential (Chakraborty et al., 2011). This evidence concerns the gene NR1I3 and neoplasm.