CXADR and neoplasm: Although the underlying mechanisms of the significant species differences of CAR in tumor development are largely unknown, such variances might be attributed to the divergent regulation of differential genes governing DNA synthesis, cell proliferation, apoptosis, and migration by hCAR vs. its rodent counterparts (Ross et al., 2010; Kamino et al., 2011b; Takizawa et al., 2011).