To investigate whether the role of HDAC6 in mediating pancreatic cancer cell migration requires its catalytic activity, we treated cells with tubacin, a potent and selective HDAC6 inhibitor (Haggarty et al., 2003), and trichostatin A (TSA), a pan-HDAC inhibitor (Lindemann et al., 2004). Here, HDAC6 is linked to familial pancreatic carcinoma.