CD8A and neoplasm: Necrotic cell death results in the release of ATP from dying tumor cells into the extracellular space (Martins et al., 2009), which can be sensed by purinergic receptors on the surface of DCs, resulting in activation of tumor-antigen specific type-1 T helper cells (Th1) and cytotoxic CD8 T cells (Idzko et al., 2002; Elliott et al., 2009; Zitvogel et al., 2012).