Initially, the idea was that this effect could be mediated by binding to beta-adrenergic receptors, leading to reducing of pro-angiogenic factors like VEGF (vascular endothelial growth factor) and b-FGF (fibroblast growth factor beta).8 It has already been shown that infantile hemangiomas express adrenergic receptors and are closely related to sympathetic innervation.9 The gene discussed is FGF2; the disease is capillary hemangioma.