In this respect, the property whereby macroH2A1.1 binds with very tight affinity with OAADPR produced by SIRT1 is intriguing, considering that the activation of these enzymes is considered protective against NAFLD favouring a overall healthy aging [38], and is under scrutiny for drug design [39, 40]. The gene discussed is MACROH2A1; the disease is metabolic dysfunction-associated steatotic liver disease.