The suggested role of PTPR variations in protracted GF signaling suggests the time of accelerated growth during 6–12 months of age for beginning pharmaceutical interventions targeting Ca2+ signaling, from the time where a decline in eye fixation and atypical pattern in scanning of faces and social scenes can be observed120,126,127 to the time where language regression is seen in some children128 at the begin of the ‘stranger anxiety' period,129 while interventions targeting downstream mTOR signaling130 might be most effective when started even earlier, before symptoms are seen. Here, PTPRR is linked to Anxiety.