VEGFA and wet macular degeneration: New treatments for wet AMD reached the clinic in the mid-2000s and now wet AMD is fairly well controlled by treatment with anti-vascular endothelial growth factor (VEGF) antibodies ranibizumab or bevacizumab, the anti-VEGF agent aflibercept that contains portions of the VEGF-binding domains of the human VEGF receptors 1 and 2 or the polyethylene glycol modified RNA aptamer pegaptanib [16].