Fibronectin also induces gelatinase B/MMP-9 expression in ovarian cancer cells through FAK and ras activation [335] and laminin has been shown to up-regulate gelatinase B/MMP-9 expression in macrophages and in A2058 melanoma cells but not in other malignant tumour cells [341,342]. The gene discussed is FN1; the disease is melanoma.