Furthermore, neutrophil-derived gelatinase B/MMP-9 has been implicated in inflammation-associated lymphangiogenesis, promoting VEGF-A bioavailability and bioactivity [314] and, together with VEGF-C, has been implicated in lymphangiogenesis and lymph node metastasis in breast cancer [315]. The gene discussed is MMP9; the disease is metastatic malignant neoplasm in the lymph nodes.