SPARC and neoplasm: Angiogenic fibroblast growth factors induce gelatinase B/MMP-9 expression in tumour and stromal tissues [153,300,301], and agents that inhibit MMP9 expression and/or gelatinase B/MMP-9 activity, such as DMBT [302], propofol [303], secreted protein acidic and rich in cysteine (SPARC) [304], S100A4 [305], xylitol [306], wortmanin [235], BMP4 [307], and aloe emodin [308], down regulate angiogenesis in different models.