MMP9 and central nervous system cancer: Furthermore, transcriptional silencing of gelatinase B/MMP-9 inhibits human glioma cells proliferation [208] and Wnt signalling induced by hypoxia stimulating gelatinase B/MMP-9 expression and promotes neural stem cell proliferation [217], suggesting that a hypoxia/Wnt/gelatinase B/MMP-9 axis may also promote proliferation of the cancer stem/progenitor cell component of neural-related tumours.