Gelatinase B/MMP-9 is considered to be a tuner and amplifier of inflammatory and immune functions [106,238] and is up regulated by pro-inflammatory cytokines such as TNFα, IL-1β, IL-6 and TGFβ in a wide variety of human tumour cells, stromal and endothelial cells [12,13,15]. This evidence concerns the gene TNF and neoplasm.