Indeed, fibroblast gelatinase B/MMP-9 enhances endothelial cell survival and function [271], gelatinase B/MMP-9 from circulating macrophages promotes angiogenesis in a model of pancreatic cancer [272] and increased tumour cell gelatinase B/MMP-9 promotes angiogenesis in a model of neuroblastoma [265]. The gene discussed is MMP9; the disease is familial pancreatic carcinoma.