In addition, the higher ratios of IFNα2 to Th2 cytokines, including IFNα2/IL4, IFNα2/IL10, IFNα2/CCL2, IFNα2/CCL7, IFNα2/CCL11, and IFNα2/TNFα, were associated with increased odds of ER negative vs. ER positive cancer. This evidence concerns the gene ESR1 and cancer.