In this study we assessed the effect of inhibition of the CXCL12/CXCR4 pathway by a novel CXCR4 antagonist, CTCE-9908 on in vitro cell proliferation and invasion, and in vivo orthotopic tumor growth, metastasis, and angiogenesis of PC cells. The gene discussed is CXCR4; the disease is pachyonychia congenita.