The first signal of the possible role of a dysfunction in cerebral cortex in Lafora disease came form the evidence that in 3 months-old EPM2A-/- all the LBs were specifically located in GABAergic neurons (GABAergic cells: so called because their neurotransmitter is gamma-aminobutyric acid or GABA) of the cerebral cortex (Figure 1), while LBs were located in all types of neurons in mice over 3 months old. This evidence concerns the gene EPM2A and Lafora disease.