EPM2A and early-onset autosomal dominant Alzheimer disease: In addition, we highlight the presence of actin disarrangement in cortical neurons of EPM2A-/- mice, which resembles the characteristics of other neurodegenerative disease, such as Alzheimer’s disease, where actin deposits have been found in the hippocampus and the cerebral cortex of post-mortem brains, predominantly localized in amyloid containing neurites[39].