While these are the only studies to have examined mGluR5 binding in schizophrenia, Deschwanden et al. [21] reported region-specific reductions in [11C]ABP688 in-vivo binding to the MPEP site in the PFC, insula, and parts of the parietal and temporal cortices in living patients with depression. The gene discussed is GRM5; the disease is major depressive disorder.