The decrease in Mcl-1 by ponatinib in CEL cells may facilitate apoptosis, because silencing Mcl-1 with siRNA significantly potentiated the ponatinib-mediated apoptosis in EOL-1 cells, which is in line with the finding that decreased Mcl-1 level sensitizes leukemia cells to tyrosine kinase inhibitors [22]. This evidence concerns the gene MCL1 and leukemia.