Given the FDA approval of oral ponatinib in patients with refractory CML and Ph + ALL resistant to the first- and second-generation of TKIs [39], our findings warrant a clinical trial of ponatinib in imatinib-resistant CEL and other malignant disorders harboring T674I PDGFRα. This evidence concerns the gene PDGFRA and chronic myelogenous leukemia, BCR-ABL1 positive.