While there are reports on increased insulin resistance due to certain serum uric acid levels increasing blood flow and causing vasodilation to interfere with the action of nitric oxide, which facilitates glucose absorption[18], other results suggest that hyperuricemia is caused by hyperinsulinemia due to insulin resistance acting on the renal tubules to facilitate the reabsorption of uric acid[19,20]. This evidence concerns the gene INS and Hyperinsulinemia.