It is possible that further developmental delay (that is, in progressing from L4 to adulthood) could contribute to the lifespan extension, although given that oxa-1(RNAi) animals, on average, took twice as long to reach adulthood, the delay from L4 to adulthood would only be expected to contribute to lifespan extension by a maximum of one day, and observed lifespan extension was much more pronounced than this. The gene discussed is OXA1L; the disease is Global developmental delay.