Selective IFN-β-induced activation of Jak1 and higher STAT-1 phosphorylation upon IFN-β vs. IFN-α treatment were observed [116] in both human myocardial fibroblasts and vascular endothelial cells [117], and a superior antiproliferative effect of IFN-β over IFN-α was shown in Ewing’s sarcoma cells in vitro[118]. This evidence concerns the gene JAK1 and Ewing sarcoma.