Some other studies indicated lower level of FOX-P3 in both CTCL (Cutaneous T Cell Lymphoma) and ATLL (Adult T Cell Leukemia/ Lymphoma) with some that demonstrated CD4+CD25+dysfunction due to viral gene product-HTLV-I tax ,that is responsible for neurological manifestation of the HTLV-I patients (21-23). The gene discussed is CD4; the disease is adult T-cell leukemia/lymphoma.