To examine association between HLA class I alleles and HAM/TSP HLA-typing was performed by PCR-SSP method to determine HLA-A*02, HLA-Cw*08, HLA-A*24 and HLA-B*54 in 50 HTLV-I infected individuals (20 HAM/TSP and 30 asymptomatic carriers).we couldn’t find any association between these class I alleles including (HLA-A*02, HLA-A*24, HLA-Cw*08) and risk of HAM/TSP development. This evidence concerns the gene HLA-B and tropical spastic paraparesis.