It was exciting for us to find that the exogenous ligand Tipα binds to surface nucleolin on human gastric cancer cell lines and that internalization of the Tipα and nucleolin complex induces tumor progression and epithelial–mesenchymal transition (EMT) in human gastric cancer (Suganuma et al. 2008; Watanabe et al. 2013): Our study showed that the binding of Tipα to surface nucleolins is an essential step for H. pylori carcinogenesis in humans. This evidence concerns the gene NUCLEOLIN and gastric cancer.