NUCLEOLIN and signet ring cell carcinoma: The amount of surface nucleolin was found to be large in MKN-45 (poorly differentiated adenocarcinoma), KATOIII (signet ring cell carcinoma), MKN-74 (moderately differentiated adenocarcinoma), and AGS (adenocarcinoma) cells; the amount was small in MKN-1 (adenosquamous carcinoma) cells, but all five cell lines contained similar amounts of nucleolin in the whole cell lysates (Watanabe et al. 2010a).