Therefore, as in the work by Ohmura et al. [29], it is possible that the renoprotective effect of telmisartan may be induced at least in part by inhibition of the renal hypertensive effect of angiotensin II based on the antagonistic activity to the AT1 receptor, but also by its non-hemodynamic effects in relation to cell proliferation, renal sclerosis and fibrosis stimulated by angiotensin II [30]. This evidence concerns the gene AGT and nephrosclerosis.