In conclusion, this is the first study in which LDL oxidative susceptibility and response to HDL incubation, serum APOA1 as well as mRNA hepatic expression and urinary albumin excretion are analysed in an obesity related type II diabetes rat model subjected to either a dietary intervention or a pharmacologic modulation of PPAR gamma with telmisartan. The gene discussed is APOA1; the disease is type 2 diabetes mellitus.