In addition, the role of peroxisome proliferator-activated receptor-γ (PPAR-γ) in adipocyte differentiation, the antiproliferative and/or differentiating effects of PPAR-α and PPAR-γ ligands in human colon and other tumor cell lines, and the anticancer effects of both PPAR isotypes in animal models of CRC support a chemoprotective role for these nuclear hormone receptors [10,11]. This evidence concerns the gene PPARG and colorectal carcinoma.