Studies in rodent models of colorectal and other tumors, as well as in human normal and tumor cell lines have shown PPAR-γ ligands to exert powerful anti-cancer effects; these effects appear mediated by the differentiating, pro-apoptotic, and anti-proliferative effects on malignant cells, as well as by the anti-inflammatory actions of PPAR-γ [10,11]. The gene discussed is PPARG; the disease is neoplasm.