Alzheimer’s disease (AD) is a devastating neurodegenerative disorder which is characterized by two principal features: i) intracellular accumulation of hyperphosphorylated tau protein constituting neurofibrillary tangles (NFT) and neuropil threads; and ii) extracellular accumulation of β-amyloid (Aβ) peptide, major component of diffuse, focal and stellate deposits – the focal deposit constituting the core of the senile plaques [1]. The gene discussed is MAPT; the disease is Alzheimer disease.