Through comprehensive quantification of those morphological indices in the second sacral segment from two groups of patients with ALS deceased early or late after the onset, it was possible to compare the differences of morphology and neuronal counts in each; 1) region (ON, dorsolateral alpha-motoneuron group and the other areas), 2) phase (early and advanced), and to assess possible influences of TDP43-positive inclusions to these changes. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.