Although the c.2452G > A mutation has not been reported before, different mutations of ATP1A3 are known to cause two other autosomal dominant neurological diseases: rapid-onset dystonia-parkinsonism [18-20] (DYT12; OMIM: 128235) and alternating hemiplegia of childhood [21,22] (AHC; OMIM: 614820). This evidence concerns the gene ATP1A3 and Rapid-onset dystonia-parkinsonism.