Hence, we show that α(1,2)-linked fucosylated proteins are upregulated in RA synovial tissue (ST) and that fut1 in RA synovial fibroblasts is important in EC tube formation, leukocyte-synovial fibroblast adhesion, and synovial fibroblast proliferation, all critical aspects of inflammation in the RA joint synovium. This evidence concerns the gene FUT1 and rheumatoid arthritis.