The secretion of MCP-1/CCL2, ENA-78/CXCL5, and VEGF in TNF-α-stimulated fut1 siRNA-transfected RA synovial fibroblasts was significantly decreased compared with control siRNA-transfected or nontreated RA synovial fibroblasts (Figure 4D, E and F). This evidence concerns the gene TNF and rheumatoid arthritis.