TNF and rheumatoid arthritis: We found that mRNA expression of MCP-1/CCL2, ENA-78/CXCL5 and VEGF in TNF-α-stimulated fut1 siRNA-transfected RA synovial fibroblasts was significantly decreased compared to control siRNA-transfected RA synovial fibroblasts (Figure 4A, B and C).