Considering the role of TWEAK in stimulating autophagy and impairing myogenesis, we hypothesized that the TWEAK-Fn14 axis may be involved in the pathomechanism of PM/DM and set out to study whether TWEAK-Fn14 participates in the pathogenesis of PM/DM. The gene discussed is TNFRSF12A; the disease is polymyositis.