USP22 and metastatic malignant neoplasm in the lymph nodes: Multivariate analyses showed lymph node metastasis (P  = 0.041 for OS; P  =  0.045 for DFS), Ki-67 expression (P  =  0.005 for OS; P  =  0.008 for DFS), as well as USP22 expression (P  =  0.043 for OS; P  =  0.047 for DFS) were associated with poor OS and DFS.