Using a yeast two-hybrid screen, we identified Enigma as a new Cbl-c interacting protein (Figure 1) which abrogates Cbl-c-mediated ubiquitination and downregulation of RET9MEN2A, a RET isoform associated with multiple endocrine neoplasia (MEN) type 2A. The gene discussed is CBLC; the disease is multiple endocrine neoplasia type 2A.