At present, it has been reported that FTO gene influence PCOS mainly via the association with obesity or obesity-related parameters[9], [12], [14], [15], [24], [31], such as BMI, body weight, fat mass and some other metabolism-related traits[9], [14], [24], [32], such as insulin resistance, impaired fasting glucose, glucose intolerance. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.