As figure 4H showed, effector T cells (HLA A2+/A11− from patient4) stimulated by purified hybrid cells supplemented with the non-adherent cell fraction can not only lyse the auto breast tumor cells (HLA A2+/A11−, HER2+), but also lyse the HLA-A2 matched MCF7 (HLA A2+/A11−, HER2+) to a less extent ( P<0.05). Here, ERBB2 is linked to breast neoplasm.