Stimulation by auto breast tumor cells caused higher IFN-gamma secretion by T cells activated by purified hybrids, the adherent cell fraction, the non-adherent cell fraction, total fusion products, and purified hybrid cells supplemented with the non-adherent cell fraction than by adherent tumor cells, or DCs mixed with tumor cells (P<0.05; Fig. 3 patient 1, patient2, patient3). The gene discussed is IFNG; the disease is neoplasm.