PSEN2 and laryngeal carcinoma: Furthermore, in cell clones resistant to multiple anti-cancer drugs, certain changes that increase Ad5-mediated transgene expression have been characterized, including up-regulation of CAR and integrin αvβ3 in a human laryngeal carcinoma cells resistant to cisplatin CA3ST[27] or increased activity of a Rous sarcoma virus promoter driving Ad5-mediated transgene expression in human laryngeal carcinoma cells resistant to vincristine, [28].