We previously demonstrated that Crk-associated substrate lymphocyte type (Cas-L)/human enhancer of filamentation 1 (HEF1)/neural precursor cell expressed, developmentally down-regulated 9 (NEDD9) mediates cell signaling through β1 integrins [32]–[34], and that Cas-L promotes metastasis of non-small cell lung cancer cells [35]. This evidence concerns the gene NEDD9 and non-small cell lung carcinoma.