To confirm that the immunoreactive cells were indeed microglia, and to demonstrate that C/EBPβ immunoreactive microglia were highly associated with Aβ plaques in the AD brain, sections from the superior frontal gyrus (SFG) of AD patients were double-labeled with microglia (LN3) and Aβ-specific (4G8 and 6E10) antibodies or thioflavine S. These sections also revealed that C/EBPβ immunoreactivity colocalized with microglia investing Aβ plaques and, again, failed to detect C/EBPβ-positive astrocytes (by GFAP antibody-not shown). The gene discussed is GFAP; the disease is Alzheimer disease.