In addition, other groups revealed that RNF43 expression was also elevated in adenomas of the colon [34], that it is down-regulated by a dominant-negative form of Tcf4 in LS174 colon cancer cells [35], and that expression of RNF43 was induced by Wnt3a conditioned media [25]. The gene discussed is TCF4; the disease is malignant colon neoplasm.