MAPK8 and hepatocellular carcinoma: By treating SK-Hep-1 and HA22T/VGH cells with various concentrations of LicA, it was determined that there was a significant dose-dependent decrease in the phosphorylation of JNK1/2 in HCC cells, whereas there were no significant differences in the phosphorylation of ERK1/2 and p38 (Fig. 3).