CAMK2A and amyotrophic lateral sclerosis: As transgenic lines driven by the CaMKIIα promoter or bearing the M337V mutation have already been reported that do exhibit these phenotypes [21], [24], [33], the absence here of early lethality or gait disturbance cannot be entirely explained by these variables alone, suggesting that a combination of these and other factors such as timing of transgene expression and background strain govern ALS-like phenotypes.