FGFR3 and cancer: To begin to investigate the integration of TAK1 and FGFR3 signaling in cancer cells, we performed a comparative microarray analysis of gene expression in the MGHU3 bladder cancer cell line, which expresses the FGFR3 Y375C activating mutation and exhibits strong responses to the FGF receptor-specific PD173074 inhibitor as assessed by ERK phosphorylation [9].