In this report, we provide evidence of a role for a highly integrated interaction between FGFR3 and TAK1 in bladder cancer and MM cases in which FGFR3 is implicated, laying the ground work for further understanding of these cancers and/or identification of other cancers in which these intersecting pathways are impacted. This evidence concerns the gene FGFR3 and urinary bladder carcinoma.