Although this possible cross-talk has not been clarified in studies with experimental diet-induced obesity models, our initial hypothesis is that obesity is associated with AT1R and MAPK activation and, as consequence, cardiac remodeling and insulin cascade inhibition due to tyrosine phosphorylation reduction of key insulin pathway messengers in the myocardium. The gene discussed is AGTR1; the disease is obesity due to melanocortin 4 receptor deficiency.