Experimental evidence has shown that diet-induced obesity is associated with cardiac remodeling, substantiated by contractile disturbances [4]–[8], hypertrophy [4]–[9], interstitial fibrosis [5], [7], and molecular expression changes in contractile proteins including myosin heavy chain (MyHC) β isoform synthesis [5], [7], and endocrine disturbances such as insulin and glucose metabolism disorders [6]–[9]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.