With respect to MAPK, Losartan normalized obesity effects, as ERK (CL 1.07±0.07; OBL 1.23±0.20AU) and JNK (CL 0.74±0.13; OBL 0.87±0.17AU) expression values were similar (p<0.05) in CL and OBL groups (Figure 4). The gene discussed is MAPK8; the disease is obesity due to melanocortin 4 receptor deficiency.