Moreover, we found that the CFC production inhibition induced by GAS2DN for CML cells was significantly higher than that for NBM cells (47±6% versus 17±8% for YFP+ cells, p = 0.02; 57±3% versus 31±1% for CD34+YFP+ cells, p = 0.01, Figure 5C), which demonstrated that GAS2DN had a stronger inhibitory effect on CFC production of CML progenitor cells than that on CFC production of normal progenitor cells. The gene discussed is CD34; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.