Recently several DUBs have been shown to be involved in cancer progression [41], for example UCHL5 is up-regulated in human cancer including cervical carcinoma and esophageal squamous cell carcinoma (ESCC), and its expression has been identified as a poor prognostic indicator for ESCC as well [42], [43]. Here, UCHL5 is linked to esophageal squamous cell carcinoma.