Similar to GLUT-1, overexpression of FIH-1 in U87 cells decreased the levels of VEGF-A mRNA (another HIF mediated gene and important for tumor angiogenesis) in both normoxia and hypoxia (Figure 4) further confirming the importance of FIH-1 in regulating HIF activity in glioblastoma. The gene discussed is SLC2A1; the disease is glioblastoma.