VEGFA and glioblastoma: Similar to GLUT-1, overexpression of FIH-1 in U87 cells decreased the levels of VEGF-A mRNA (another HIF mediated gene and important for tumor angiogenesis) in both normoxia and hypoxia (Figure 4) further confirming the importance of FIH-1 in regulating HIF activity in glioblastoma.