PTEN and cancer: Importantly, FIH-1 is located at chromosome 10q24, which is often deleted in glioblastoma, especially in secondary glioblastoma, making it an important candidate gene to study the progression of this cancer [36]–[41], while mutation of PTEN at 10q23.3 are common (12–40%) in primary glioblastoma [40], [42]–[44].