IL6 and rheumatoid arthritis: Moreover, different associations of these two mediators have been reported even in a single disease [51], as seen in our study.Actually, we think that IFNhigh RA patients might display an impaired endothelial repair partly due to their proinflammatory cytokine network, mainly represented by higher serum levels of IL-1β and IL-6 (a Th17 inducer cytokines) and low TGF-β, compared to their IFNlow counterparts.