In fact, IFNhigh RA patients showed cytokine disturbances closer to SLE patients, characterized by a proinflammatory profile and higher IL-10 levels, which are associated with disease activity and poor prognosis markers, suggesting that this cytokine could be acting as a proinflammatory mediator in these conditions, as some authors have reported [47], [48]. This evidence concerns the gene IL10 and systemic lupus erythematosus.