Recent genomic studies have reported the presence of type I IFN signature in around 25–50% of RA patients [28]–[30], [39], which is according to our IFNhigh subset size (30%) and using similar criteria as cut off (90th percentile), but no correlations had been detected between IFN signature and clinical or immunological disease parameters. Here, IFNA1 is linked to rheumatoid arthritis.