Since there is evidence to suggest that SOD1 and TDP43 may interact [20]–[22], and in order to establish whether motor dysfunction may manifest in Tardbp+/Q101X mice in the presence of an ALS-related stress, Tardbp+/Q101X mice were crossed with SOD1G93Adl transgenic mice which have been previously been shown to model ALS, including deterioration of hindlimb neuromuscular function and a shortened lifespan ranging between 31–38 weeks [64]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.